SURVEY. Patient Knowledge and Attitudes Regarding Fecal Microbiota Therapy
for Clostridium difficile Infection
At any time patients may ask questions. These questions will be recorded in writing and compiled to determine which
questions are most common. No elements of protected health information will be recorded as part of this interview.
Hello, my name is (interviewer’s name), and I am part of a research project that assesses patient attitudes about a
particular treatment for Clostridium difficile (C difficile) infection of the intestines for which you are being treated. We
learned about your infection from the Microbiology Laboratory/your treating team.
The research project involves asking patients who have this infection about 12 to 17 questions on a potential new
treatment and whether they would be interested in the treatment if it were available.
Would you be willing to spend 10 to 20 minutes answering these questions about C difficile and this treatment that
we will tell you about? Your responses will help determine whether it is feasible to study this treatment in this or in
other VA facilities. There is no benefit to you for participating in this study.
1. Are you willing to continue with this study?
No—Thank you. If you change your mind and want to participate, please call this telephone number.
C difficile infection is a bacterial infection of the intestines that leads to diarrhea and occasionally more severe
symptoms. C difficile is typically triggered by antibiotic treatment, which can destroy the normal bacteria that
live in healthy intestines. This disruption of the normal bacteria allows C difficile bacteria to multiply and cause
Current therapy for C difficile involves using antibiotics to kill the C difficile, which then allows the normal
bacteria grow back. First-line treatment is with 10 to 14 days of an antibiotic called metronidazole or a
different antibiotic called vancomycin. For recurrent episodes, longer courses of metronidazole, vancomycin,
or other antibiotics are used.
2. Have you ever had C difficile in the past? (Yes—Continue; No—Go to question 7.)
3. How many episodes of C difficile have you had?
4. Have you ever had a C difficile infection severe enough to require intensive care stay?
5. On a scale of 1 to 10, if 1 represents no limitation whatsoever and 10 represents severe limitation in your
quality of life, how would you say your C difficile infections have affected your quality of life?
6. What treatments for C difficile have you received in the past? If you do not know, would you permit us to
review your chart to determine which treatments you have had?
7. After a first episode of C difficile, assuming proper treatment, what percentage of patients do you think
would be expected to have a second (or recurrent) episode? (Record answer.)
After the first C difficile infection, we actually expect 20% to 30% of patients to have a second episode.
8. If a person gets a second episode of C difficile and is treated properly, what percentage would be expected
to have a third episode (or a second recurrence)? (Record answer.)
After the third episode of C difficile, up to 50% of patients may have recurrence.
9. Have you heard of fecal microbiota treatment, more commonly known as a stool transplant? (Yes—Go on.
No—Go to text after question 10.)